Vitamin B17 is a commonly used name for a chemical called amygdalin. It is used to make a chemical called laetrile, a compound that some people claim can treat cancer naturally. However, there is little evidence that laetrile works or is safe.
Amygdalin is sourced from certain plant products like apricot pits and bitter almonds. Although they're called "vitamin B17," amygdalin and laetrile are not B vitamins.
This article will define what vitamin B17 is. You will also learn about the claims made about amygdalin and laetrile, as well as the side effects and safety concerns linked to them.
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What Is Vitamin B17 Used For?
Some people claim that laetrile is an effective natural cancer treatment and that it can also protect against high blood pressure and arthritis. However, little scientific evidence supports any of these uses.
Laetrile is not approved by the Food and Drug Administration (FDA) for any use, including as a cancer treatment. In fact, in 2019, the FDA issued an import alert for laetrile based on a lack of evidence for its effectiveness and its status as an unapproved drug.
The National Cancer Institute (NCI) states that there is no evidence that our bodies need laetrile or that it acts as a vitamin in animals or humans.
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How Vitamin B17 Is Claimed to Work
Claims that vitamin B17 is a natural cancer fighter rests on a mechanism called apoptosis, which is a type of cell death that takes place because a cell is cancerous or infected, or because it is time for new cells to replace it. Apoptosis is one of the ways your body keeps itself healthy.
When you consume amygdalin, your body converts it to cyanide, a chemical that can be lethal if you consume too much of it. Some people claim that the small amount of cyanide that laetrile releases causes apoptosis (cell death) in cancer cells. The idea has been promoted for several types of cancer, including:
- Prostate
- Cervical
- Breast
- Bladder
- Lung
- Kidney
Some scientific evidence has suggested that laetrile might have some anti-cancer activity, and the findings have renewed interest in its potential effects.
However, the evidence is still preliminary and needs more follow-up research to find out the true effects of laetrile and the potential risks of using it.
Some people have claimed that cancer is caused by a deficiency of vitamin B17. They argue that consuming laetrile can reverse the deficiency and, in turn, aid with the treatment or prevention of cancer. However, there is no evidence that the body has any known uses for vitamin B17.
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How Did Laetrile Get Popular?
Laetrile's popularity has been bolstered by conspiracy theories. For decades, people have claimed that laetrile is proven to be safe and effective or that it's the target of a government cover-up of inexpensive cancer treatments.
Despite the FDA ban that went into effect in 1987, many people still take laetrile for cancer. You can get laetrile online and in some stores.
However, the products cannot legally be marketed as a cancer treatment. Still, with false claims all over the internet, people learn about laetrile and seek it out.
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Amygdalin has been used as an anticancer treatment since the mid-1800s. Laetrile was developed during the 1950s as a purportedly non-toxic version of amygdalin. Laetrile has been studied in animals and humans, but it still isn't known if or how well it works against cancer.
What Research Says About Vitamin B17
Vitamin B17 could be worth studying more, but the research so far has only been done on cells in a petri dish or on animals.
While this type of research can lay the foundation for clinical trials with people, the science is not at that stage yet.
Promising Research
Some research on laetrile and amygdalin as cancer treatments has been published in reputable journals. For example:
- In 2021, researchers said that they uncovered the mechanisms by which amygdalin induces apoptosis: It appeared to increase one cellular protein and reduce another. They also saw other beneficial actions at the cellular level, stating that "amygdalin possesses anticancer properties and induces apoptosis," and that "amygdalin can act as a multifunctional drug in cancer therapeutics."
- In August 2020, researchers said they demonstrated that amygdalin can kill certain breast cancer cell lines and that amygdalin may prevent those cells from spreading through the body. They also stated that it was not toxic to healthy skin cells.
- In June 2020, researchers combined amygdalin with an enzyme called beta-glucosidase (ß-glu), which enhances amygdalin activity. They found that the combination led to the death of prostate cancer cells. They also noted that while the treatment had some impact on heart and liver function, it did not appear to cause organ damage.
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Inconclusive Evidence
The studies that have been done have not been clear about whether amygdalin could be more effective against certain types of cancer than others.
The scientists doing the studies have said that there is a need for more research to determine what role amygdalin might play in cancer treatment.
There are several important considerations for something like laetrile to be an effective cancer treatment, such as:
- It needs to be delivered in appropriate and consistent dosages—which have not yet been established and likely are not possible to get through diet or unregulated commercial products.
- It needs to be able to survive the digestion process and the body's other protective mechanisms until it can get into the bloodstream and tissues in amounts high enough to be therapeutic.
- It should combine with or be broken down by the body's enzymes and other substances in ways that make it useful rather than inactive or harmful.
- How a person responds to it could be influenced by the makeup of their gut microbiota (the mix of bacteria in the digestive system).
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Criticisms
A review of research evidence on amygdalin published in 2016 highlighted some of the key criticisms that are important to keep in mind. For example, the researchers said that:
- Several aspects of amygdalin use "haven't yet been adequately explored, making further investigation necessary to evaluate its actual therapeutic potential."
- Claims that laetrile or amygdalin can benefit cancer patients are not supported by sound clinical data.
- None of the previous studies evaluated were high quality enough to meet the reviewers' criteria. They concluded that the consumption of amygdalin carries a considerable risk of serious adverse effects resulting from cyanide poisoning. The authors of one review concluded that "due to the risk of cyanide poisoning, the use of laetrile or amygdalin should be discouraged."
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Food Sources of Vitamin B17
If you want to get more amygdalin naturally, there are some food sources to consider adding to your diet. However, it's not a miracle cure. You also need to avoid consuming too much vitamin B17, which can lead to cyanide poisoning.
Natural sources of amygdalin include:
- Raw almonds
- Lima beans, mung beans, and butter beans
- Clover
- Sorghum
- Carrots
- Celery
- Bean sprouts
- Nuts
- Flaxseed
Although it is technically possible to consume a lethal dose of amygdalin when you eat these foods, you would have to eat much more than most people typically consume in one day.
However, because amygdalin is present in many different foods as well as in drinking water, there is some concern that people who regularly consume these foods could be exposed to concentrations of cyanide that are large enough to cause chronic health problems. For this reason, you should consume these foods in moderation.
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Side Effects and Safety Concerns with Vitamin B17
The B17 products that are commercially available have not been proven to be safe or effective, and they are not regulated.
Many laetrile products that are commercially available in the United States come from Mexico and they are untested. In some cases, contaminated products have been found. These products may pose serious threats to your health that go beyond the risks of using laetrile.
Laetrile-containing products have been found to trigger a range of side effects that are similar to those of cyanide poisoning. For example, they can cause:
- Blue coloring of the skin
- Confusion
- Nerve damage
- Dizziness
- Droopy upper eyelids
- Headache
- Liver damage
- Low blood pressure
- Nausea and vomiting
- Fever
- Coma
- Death
In fact, some people who use vitamin B17 as a cancer treatment die from cyanide toxicity.
Cyanide poisoning is a life-threatening emergency. If you or someone you know is experiencing these symptoms, you need to get immediate medical help.
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In one study, researchers wanted to understand why some people who take amygdalin get cyanide toxicity and others do not. They also wanted to find out why it's more common when amygdalin is consumed compared to when it's injected.
The researchers discovered that certain gut bacteria have high levels of the enzyme ß-glu, which converts amygdalin to the toxin hydrogen cyanide (HCN).
A person's ß-glu levels can be influenced by several factors, including:
- Taking prebiotics or probiotics
- Other supplements or natural products they use
- Obesity
- Diet
- Age
Vitamin C may boost the amount of cyanide that laetrile releases in your body. That means that it could raise the risk of toxicity.
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Alternatives to Vitamin B17
If you're thinking about using vitamin B17 for the prevention or treatment of cancer, you need to know about and understand the potential threats to your health. Talk to your provider about the safest and most effective way to treat or prevent cancer.
There's no proven way to eliminate the risk of all cancers, but there are some practices that we know support your overall health and may help reduce your risk for disease, including cancer.
For example:
- Avoiding smoking and tobacco use
- Getting recommended cancer screenings
- Following a nutritious diet
- Exercising regularly
- Maintaining an optimal weight
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Summary
Vitamin B17 is sometimes used to describe the chemicals amygdalin and laetrile. Despite the name, these chemicals are not really vitamins. Vitamin B17 is sometimes used as a natural cancer treatment. Research on vitamin B17 is limited, however, and to date there is little evidence that it works against cancer.
Vitamin B17 can be found in foods like raw almonds, flaxseed, bean sprouts, and lima beans. When you eat these foods, the chemical amygdalin is converted to small amounts of the poison cyanide. Although you would have to eat a lot of these foods to consume a lethal dose of cyanide, it is possible that smaller amounts could cause chronic health problems.
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